I think a lot of intellectual energy over the centuries has gone into religious matters. Think of all the monks devoting themselves to fine points of theological doctrine -- monks and rabbis and bonzes and Moabs, imams, down through the years devoting so much talent and energy to questions of theology. In a way science provides an alternative way of using your mind. This is something else where you can use human intelligence. It has several advantages. It has the advantage that we have ways of finding out we're wrong about things. I've had that experience in my life -- most scientists have -- of having a theory that I thought was bound to right shown to be wrong by experiments -- its a very cleansing experience. (Nobel-prize-winning physicist Steven Weinberg, Interview, via The Secular Outpost.)
Not the Godol Hador finally gets around to asking, "Is Orthodox Judaism Bad for You?" He lists several possible reasons it is, mostly about moral or ethical questions regarding Orthodox Jewish beliefs and halakha. In the comments, I added the following comment before passing along Weinberg's quote:
What about the wasting of some of the world's best minds? If a Talmudic genius were raised by atheists instead of hasidim, perhaps he would have cured cancer. Perhaps a cohen not going to medical school because of gross anatomy would have saved a thousand lives. What about all the Hasidic or RWO [right-wing Orthodox] women raising 12 kids despite having minds as keen as any man's?
Obviously, I'm not saying there's no place for Talmudic scholars or women who want twelve kids -- it should of course be their choice -- but raising another generation of Orthodox youth might have negative effects beyond the ones you listed.